AUTHOR=Hovine Agathe , Chauleur Céline , Gauld Christophe , Rancon Florence , Gris Jean-Christophe , Tardy Brigitte , Giraud Antoine , Raia-Barjat Tiphaine 

TITLE=Serum D-dimer is not predictive of placenta-mediated complications in pregnancy at high risk: The multicentric prospective cohort AngioPred study

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1115622

DOI=10.3389/fcell.2023.1115622

ISSN=2296-634X

ABSTRACT=<p><bold>Background:</bold> The theory that D-dimer level might has a predictive or diagnostic role in preeclampsia needs to be explored. Aim of the study was to evaluate the association between serum D-dimer level and the occurrence of placenta-mediated complications (PMC) in a pregnant population at high risk.</p><p><bold>Methods:</bold> A prospective multicenter cohort study including 200 pregnant women was conducted.</p><p><bold>Results:</bold> Serum D-dimer increases throughout pregnancy, with the highest levels at the end of gestation. Serum D-dimer level was similar for women with PMC and with no complication. Serum D-dimer level was not different in women with preeclampsia <italic>versus</italic> uncomplicated women. Serum D-dimer level was not different in women with early or late preeclampsia <italic>versus</italic> uncomplicated women.</p><p><bold>Conclusion:</bold> This result suggests that serum D-dimer level was not predictive of the PMC occurrence. This corroborates the fact that the origin of PMC based more on immunity than in hemostasis.</p>