AUTHOR=Ahmed Noorya Yasmin , Knowles Rhys , Liu Lixinyu , Yan Yiming , Li Xiaohan , Schumann Ulrike , Wang Yumeng , Sontani Yovina , Reynolds Nathan , Natoli Riccardo , Wen Jiayu , Del Pino Isabel , Mi Da , Dehorter Nathalie TITLE=Developmental deficits of MGE-derived interneurons in the Cntnap2 knockout mouse model of autism spectrum disorder JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=11 YEAR=2023 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1112062 DOI=10.3389/fcell.2023.1112062 ISSN=2296-634X ABSTRACT=
Interneurons are fundamental cells for maintaining the excitation-inhibition balance in the brain in health and disease. While interneurons have been shown to play a key role in the pathophysiology of autism spectrum disorder (ASD) in adult mice, little is known about how their maturation is altered in the developing striatum in ASD. Here, we aimed to track striatal developing interneurons and elucidate the molecular and physiological alterations in the