AUTHOR=Li Ke , Ran Beibei , Wang Yu , Liu Lulu , Li Weidong TITLE=PLCγ2 impacts microglia-related effectors revealing variants and pathways important in Alzheimer’s disease JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.999061 DOI=10.3389/fcell.2022.999061 ISSN=2296-634X ABSTRACT=
Alzheimer’s disease (AD) is an irreversible neurodegenerative disease mainly characterized by memory loss and cognitive decline. The etiology of AD is complex and remains incompletely understood. In recent years, genome-wide association studies (GWAS) have increasingly highlighted the central role of microglia in AD pathology. As a trans-membrane receptor specifically present on the microglia in the central nervous system, phosphatidylinositol-specific phospholipase C gamma 2 (PLCγ2) plays an important role in neuroinflammation. GWAS data and corresponding pathological research have explored the effects of