AUTHOR=Riegel Kristina , Vijayarangakannan Parthiban , Kechagioglou Petros , Bogucka Katarzyna , Rajalingam Krishnaraj TITLE=Recent advances in targeting protein kinases and pseudokinases in cancer biology JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.942500 DOI=10.3389/fcell.2022.942500 ISSN=2296-634X ABSTRACT=

Kinases still remain the most favorable members of the druggable genome, and there are an increasing number of kinase inhibitors approved by the FDA to treat a variety of cancers. Here, we summarize recent developments in targeting kinases and pseudokinases with some examples. Targeting the cell cycle machinery garnered significant clinical success, however, a large section of the kinome remains understudied. We also review recent developments in the understanding of pseudokinases and discuss approaches on how to effectively target in cancer.