AUTHOR=Xuan Wanling , Tipparaju Srinivas M. , Ashraf Muhammad 

TITLE=Transformational Applications of Human Cardiac Organoids in Cardiovascular Diseases

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.936084

DOI=10.3389/fcell.2022.936084

ISSN=2296-634X

ABSTRACT=<p>Organoid technology has significantly advanced in recent years and revolutionized the field for generation of organs using <italic>in vitro</italic> systems (a.k.a “organs in a dish”). The use of pluripotent stem cells or tissue derived cells for generating a 3-dimensional culture system to recapitulate the architecture and function of the organ is central in achieving and improving organoid systems. Unlike most organs in the body, very little progress has been made in cardiac organoid due to its structural complexity and vascularization. In this review, we will discuss the current applications of human cardiac organoids for cardiac disease modeling, drug discovery, drug cardiotoxicity testing, and clinical applications.</p>