AUTHOR=Chen Huarong , Wang Yifei , Su Hao , Zhang Xiaoting , Chen Hongyan , Yu Jun 

TITLE=RNA N6-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.935224

DOI=10.3389/fcell.2022.935224

ISSN=2296-634X

ABSTRACT=<p>N<sup>6</sup>-Methyladenosine (m<sup>6</sup>A) is the most abundant modification on eukaryote messenger RNA and plays a key role in posttranscriptional regulation of RNA metabolism including splicing, intracellular transport, degradation, and translation. m<sup>6</sup>A is dynamically regulated by methyltransferases (writers), RNA-binding proteins (readers), and demethylases (erasers). Recent studies demonstrate that perturbation of m<sup>6</sup>A regulators remarkably influences cell fate transitions through rewiring various biological processes, such as growth, differentiation, and survival. Moreover, aberrant m<sup>6</sup>A modification is implicated in a variety of diseases, in particular cancer. In this review, we describe the functional linkage of m<sup>6</sup>A modifications to cellular reprogramming and cancer stemness properties.</p>