AUTHOR=Lopez-Tello Jorge , Salazar-Petres Esteban , Webb Liam , Fowden Abigail L. , Sferruzzi-Perri Amanda N. TITLE=Ablation of PI3K-p110alpha Impairs Maternal Metabolic Adaptations to Pregnancy JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.928210 DOI=10.3389/fcell.2022.928210 ISSN=2296-634X ABSTRACT=
Pregnancy requires adaptations in maternal metabolism to support fetal growth. The phosphoinositol-3-kinase (PI3K) signalling pathway controls multiple biological processes and defects in this pathway are linked to metabolic disorders including insulin resistance and glucose intolerance in non-pregnant animals. However, relatively little is known about the contribution of PI3K signalling to the maternal metabolic adaptations during pregnancy. Using mice with partial inactivation of the PI3K isoform, p110α (due to a heterozygous dominant negative mutation;