AUTHOR=Tan Nannan , Liu Tianhua , Wang Xiaoping , Shao Mingyan , Zhang Miao , Li Weili , Ling Guanjing , Jiang Jinchi , Wang Qiyan , Li Jing , Li Chun , Wang Wei , Wang Yong TITLE=The multi-faced role of FUNDC1 in mitochondrial events and human diseases JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.918943 DOI=10.3389/fcell.2022.918943 ISSN=2296-634X ABSTRACT=

Mitophagy plays a vital role in the selective elimination of dysfunctional and unwanted mitochondria. As a receptor of mitophagy, FUN14 domain containing 1 (FUNDC1) is attracting considerably critical attention. FUNDC1 is involved in the mitochondria fission, the clearance of unfolded protein, iron metabolism in mitochondria, and the crosstalk between mitochondria and endoplasmic reticulum besides mitophagy. Studies have demonstrated that FUNDC1 is associated with the progression of ischemic disease, cancer, and metabolic disease. In this review, we systematically examine the recent advancements in FUNDC1 and the implications of this protein in health and disease.