AUTHOR=Kang Fanhua , Jiang Feng , Ouyang Lingzi , Wu Shangjun , Fu Chencheng , Liu Ying , Li Zhilan , Tian Yu , Cao Xiaolan , Wang Xiaoping , He Qingchun TITLE=Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.886191 DOI=10.3389/fcell.2022.886191 ISSN=2296-634X ABSTRACT=

Exosomes, a type of extracellular vesicles (EVs), are secreted by almost all cells and contain many cellular constituents, such as nucleic acids, lipids, and metabolites. In addition, they play a crucial role in intercellular communication and have been proved to be involved in the development and treatment of gastrointestinal cancer. It has been confirmed that long non-coding RNAs (lncRNAs) exert a range of biological functions, such as cell metastasis, tumorigenesis, and therapeutic responses. This review mainly focused on the emerging roles and underlying molecular mechanisms of exosome-derived lncRNAs in gastrointestinal cancer in recent years. The biological roles of exosomal lncRNAs in the pathogenesis and therapeutic responses of gastrointestinal cancers were also investigated.