AUTHOR=Casamitjana Joan , Espinet Elisa , Rovira Meritxell 

TITLE=Pancreatic Organoids for Regenerative Medicine and Cancer Research

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.886153

DOI=10.3389/fcell.2022.886153

ISSN=2296-634X

ABSTRACT=<p>In recent years, the development of <italic>ex vivo</italic> organoid cultures has gained substantial attention as a model to study regenerative medicine and diseases in several tissues. Diabetes and pancreatic ductal adenocarcinoma (PDAC) are the two major devastating diseases affecting the pancreas. Suitable models for regenerative medicine in diabetes and to accurately study PDAC biology and treatment response are essential in the pancreatic field. Pancreatic organoids can be generated from healthy pancreas or pancreatic tumors and constitute an important translational bridge between <italic>in vitro</italic> and <italic>in vivo</italic> models. Here, we review the rapidly emerging field of pancreatic organoids and summarize the current applications of the technology to tissue regeneration, disease modelling, and drug screening.</p>