AUTHOR=Diana Paula , Carvalheira Gianna Maria Griz 

TITLE=NIBAN1, Exploring its Roles in Cell Survival Under Stress Context

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.867003

DOI=10.3389/fcell.2022.867003

ISSN=2296-634X

ABSTRACT=<p>Cell survival must quickly activate specific mechanisms that enable to detect changes in the cellular microenvironment. The impact of these cell alteration has direct consequences on cellular homeostasis. Cellular stress, as well as its regulation and implication, has been studied in different pathologies. In this sense, the alteration in <italic>NIBAN1</italic> expression seems to act in response to different cellular disturbances. Over the years, the knowledge of <italic>NIBAN1</italic> functions has improved, demonstrating its important cell roles, favoring the cell survival under stress context. In response to the disturbances, <italic>NIBAN1</italic> seems to be involved in the decision-making process between cell survival and death. The increase in <italic>NIBAN1</italic> expression has been related to cellular mechanisms that seek to minimize the damage caused to cellular homeostasis. In this review, the main biological insights attributed to the <italic>NIBAN1</italic> gene in different cellular contexts and its role as a mediator of cellular stress are discussed.</p>