AUTHOR=Gan Yujie , Sha Huanhuan , Zou Renrui , Xu Miao , Zhang Yuan , Feng Jifeng , Wu Jianzhong 

TITLE=Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.864101

DOI=10.3389/fcell.2022.864101

ISSN=2296-634X

ABSTRACT=<p>ADP-ribosylation is a well-established post-translational modification that is inherently connected to diverse processes, including DNA repair, transcription, and cell signaling. The crucial roles of mono-ADP-ribosyltransferases (mono-ARTs) in biological processes have been identified in recent years by the comprehensive use of genetic engineering, chemical genetics, and proteomics. This review provides an update on current methodological advances in the study of these modifiers. Furthermore, the review provides details on the function of mono ADP-ribosylation. Several mono-ARTs have been implicated in the development of cancer, and this review discusses the role and therapeutic potential of some mono-ARTs in cancer.</p>