AUTHOR=Anwar Zubair , Ali Muhammad Shahzad , Galvano Antonio , Perez Alessandro , La Mantia Maria , Bukhari Ihtisham , Swiatczak Bartlomiej 

TITLE=PROTACs: The Future of Leukemia Therapeutics

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.851087

DOI=10.3389/fcell.2022.851087

ISSN=2296-634X

ABSTRACT=<p>The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various types of Leukemia/Blood malignancies.</p>