AUTHOR=Li Wentao , Jones Kyle , Burke Tyler J. , Hossain Md Akram , Lariscy Leah 

TITLE=Epigenetic Regulation of Nucleotide Excision Repair

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.847051

DOI=10.3389/fcell.2022.847051

ISSN=2296-634X

ABSTRACT=<p>Genomic DNA is constantly attacked by a plethora of DNA damaging agents both from endogenous and exogenous sources. Nucleotide excision repair (NER) is the most versatile repair pathway that recognizes and removes a wide range of bulky and/or helix-distorting DNA lesions. Even though the molecular mechanism of NER is well studied through <italic>in vitro</italic> system, the NER process inside the cell is more complicated because the genomic DNA in eukaryotes is tightly packaged into chromosomes and compacted into a nucleus. Epigenetic modifications regulate gene activity and expression without changing the DNA sequence. The dynamics of epigenetic regulation play a crucial role during the <italic>in vivo</italic> NER process. In this review, we summarize recent advances in our understanding of the epigenetic regulation of NER.</p>