AUTHOR=van de Leemput Joyce , Wen Pei , Han Zhe TITLE=Using Drosophila Nephrocytes to Understand the Formation and Maintenance of the Podocyte Slit Diaphragm JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.837828 DOI=10.3389/fcell.2022.837828 ISSN=2296-634X ABSTRACT=
The podocyte slit diaphragm (SD) is an essential component of the glomerular filtration barrier and its disruption is a common cause of proteinuria and many types of kidney disease. Therefore, better understanding of the pathways and proteins that play key roles in SD formation and maintenance has been of great interest. Podocyte and SD biology have been mainly studied using mouse and other vertebrate models. However, vertebrates are limited by inherent properties and technically challenging