AUTHOR=He Peiwen , Ruan Dengfeng , Huang Zizhan , Wang Canlong , Xu Yiwen , Cai Honglu , Liu Hengzhi , Fei Yang , Heng Boon Chin , Chen Weishan , Shen Weiliang TITLE=Comparison of Tendon Development Versus Tendon Healing and Regeneration JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.821667 DOI=10.3389/fcell.2022.821667 ISSN=2296-634X ABSTRACT=

Tendon is a vital connective tissue in human skeletal muscle system, and tendon injury is very common and intractable in clinic. Tendon development and repair are two closely related but still not fully understood processes. Tendon development involves multiple germ layer, as well as the regulation of diversity transcription factors (Scx et al.), proteins (Tnmd et al.) and signaling pathways (TGFβ et al.). The nature process of tendon repair is roughly divided in three stages, which are dominated by various cells and cell factors. This review will describe the whole process of tendon development and compare it with the process of tendon repair, focusing on the understanding and recent advances in the regulation of tendon development and repair. The study and comparison of tendon development and repair process can thus provide references and guidelines for treatment of tendon injuries.