AUTHOR=Chen Chang , Chen Yequn , Xiao Jiaxin , Zhang Yanhong , Yang Zhaorui , Yang Peixuan , Lu Nan , Yi Kaihong , Chen Xiaojun , Chen Shaoxin , O'Gara MSc Mary Clare , O'Meara Michael , Ye Shu , Tan Xuerui 

TITLE=Association of Impaired Fasting Blood Glucose With Triple Coronary Artery Stenosis and Myocardial Infarction Among Patients With Coronary Artery Stenosis

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.820124

DOI=10.3389/fcell.2022.820124

ISSN=2296-634X

ABSTRACT=<p><bold>Background:</bold> The association between impaired fasting glucose level (IFG) and coronary heart disease (CAD) remain controversial. In the present study, we sought to ascertain a relationship of IFG with the number of diseased coronary artery and occurrence of myocardial infarction, among CAD cases.</p><p><bold>Methods:</bold> We studied 1,451 consecutive no-diabetic patients who underwent coronary angiography at the First Affiliated Hospital of Shantou University Medical College in Southern China. Demographic, biochemical, clinical and angiographic data were collected.</p><p><bold>Results:</bold> The prevalence of IFG was higher in patients with angiographically confirmed CAD than in subjects without angiographic evidence of CAD (33.4 <italic>versus</italic> 28.2%, <italic>p</italic> = 0.034). Compared with CAD cases without IFG, CAD cases with IFG had a higher odds ratio (OR) of having triple-vessel disease as opposed to having single- or double-vessel disease [OR = 1.53, 95% confidence interval (CI) = 1.13–2.07]. Furthermore, the occurrence of MI was higher in CAD cases with IFG than in CAD cases without IFG (OR = 1.73, 95% CI = 1.27–2.36).</p><p><bold>Conclusions:</bold> There is an association between IFG and a predisposition to severe CAD indicated by triple vessel disease or myocardial infarction.</p>