AUTHOR=Shi Qingyang , Chen Jiahuan , Zou Xiaodong , Tang Xiaochun 

TITLE=Intracellular Cholesterol Synthesis and Transport

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.819281

DOI=10.3389/fcell.2022.819281

ISSN=2296-634X

ABSTRACT=<p>Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in cells are balanced dynamically by uptake, biosynthesis, transport, distribution, esterification, and export. In this review, we focus on <italic>de novo</italic> cholesterol synthesis, cholesterol synthesis regulation, and intracellular cholesterol trafficking. In addition, the progression of lipid transfer proteins (LTPs) at multiple contact sites between organelles is considered.</p>