AUTHOR=Zhang Weijun , Bai Jinwu , Hang Kai , Xu Jianxiang , Zhou Chengwei , Li Lijun , Wang Zhongxiang , Wang Yibo , Wang Kanbin , Xue Deting 

TITLE=Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.817877

DOI=10.3389/fcell.2022.817877

ISSN=2296-634X

ABSTRACT=<p>Mesenchymal stem cell (MSC) transplantation has been widely used as a potential treatment for a variety of diseases. However, the contradiction between the low survival rate of transplanted cells and the beneficial therapeutic effects has affected its clinical use. Lysosomes as organelles at the center of cellular recycling and metabolic signaling, play essential roles in MSC homeostasis. In the first part of this review, we summarize the role of lysosomal acidification dysfunction in MSC senescence. In the second part, we summarize some of the potential strategies targeting lysosomal proteins to enhance the therapeutic effect of MSCs.</p>