AUTHOR=Mitchel Kira , Bergmann Jenna M. , Brent Ava E. , Finkelstein Tova M. , Schindler Kyra A. , Holzman Miriam A. , Jeannotte Lucie , Mansfield Jennifer H. TITLE=Hoxa5 Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.806545 DOI=10.3389/fcell.2022.806545 ISSN=2296-634X ABSTRACT=
The skeletal system derives from multiple embryonic sources whose derivatives must develop in coordination to produce an integrated whole. In particular, interactions across the lateral somitic frontier, where derivatives of the somites and lateral plate mesoderm come into contact, are important for proper development. Many questions remain about genetic control of this coordination, and embryological information is incomplete for some structures that incorporate the frontier, including the sternum. Hox genes act in both tissues as regulators of skeletal pattern. Here, we used conditional deletion to characterize the tissue-specific contributions of