AUTHOR=Chen Lan , Wang Li , Zhu Lingling , Xu Zihan , Liu Yanyang , Li Zhixi , Zhou Jin , Luo Feng 

TITLE=Exosomes as Drug Carriers in Anti-Cancer Therapy

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.728616

DOI=10.3389/fcell.2022.728616

ISSN=2296-634X

ABSTRACT=<p>Over the years, there has been a high demand for developing new safe and effective drug carriers for cancer therapy. Emerging studies have indicated that exosomes can serve as potent therapeutic carriers since they offer low immunogenicity, high stability, innate and acquired targetability, and the stimulation of anti-cancer immune responses. Yet, the development of exosome-based drug delivery systems remains challenging due to their heterogeneity, low yield, and limited drug loading efficiency. Herein, we summarized the current application of exosomes derived from different cells as drug carriers in anti-cancer therapy <italic>in vitro</italic> and <italic>in vivo</italic>. We also discussed the challenges and prospects of exosome-based drug delivery systems in cancer therapy.</p>