AUTHOR=Chen Qian , Shan Dan , Xie Yupei , Luo Xingrong , Wu Yuxia , Chen Qiuhe , Dong Ruihong , Hu Yayi 

TITLE=Single cell RNA sequencing research in maternal fetal interface

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.1079961

DOI=10.3389/fcell.2022.1079961

ISSN=2296-634X

ABSTRACT=<p>The maternal-fetal interface is an essential environment for embryonic growth and development, and a successful pregnancy depends on the dynamic balance of the microenvironment at the maternal-fetal interface. Single-cell sequencing, which unlike bulk sequencing that provides averaged data, is a robust method for interpreting the cellular and molecular landscape at single-cell resolution. With the support of single-cell sequencing, the issue of maternal-fetal interface heterogeneity during pregnancy has been more deeply elaborated and understood, which is important for a deeper understanding of physiological and pathological pregnancy. In this paper, we analyze the recent studies of single-cell transcriptomics in the maternal-fetal interface, and provide new directions for understanding and treating various pathological pregnancies.</p>