AUTHOR=Hayashi Chikako , Fukuda Takao , Kawakami Kentaro , Toyoda Masaaki , Nakao Yuki , Watanabe Yukari , Shinjo Takanori , Sano Tomomi , Iwashita Misaki , Yotsumoto Karen , Shida Miyu , Taketomi Takaharu , Sanui Terukazu , Uchiumi Takeshi , Kanematsu Takashi , Nishimura Fusanori TITLE=miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.1061216 DOI=10.3389/fcell.2022.1061216 ISSN=2296-634X ABSTRACT=
The expression profiles of exosomal microRNAs (miRNAs) are regulated by the microenvironment, and appropriate priming with mesenchymal stem cells (MSCs) is one of the strategies to enhance the paracrine potency of MSCs. Our previous work demonstrated that exosomes from tumor necrosis factor (TNF)-α-primed human gingiva-derived MSCs (GMSCs) could be a therapeutic tool against periodontitis, and that TNFα-inducible exosomal miR-1260b is essential for the inhibition of alveolar bone loss. However, the precise molecular mechanism underlying miR-1260b-mediated inhibition of osteoclastogenesis is not yet fully understood. Here, we found that the activating transcription factor (