AUTHOR=Ortega Miguel A. , Fraile-Martínez Oscar , García-Montero Cielo , Paradela Alberto , Asunción Sánchez-Gil María , Rodriguez-Martin Sonia , De León-Luis Juan A. , Pereda-Cerquella Claude , Bujan Julia , Guijarro Luis G. , Alvarez-Mon Melchor , García-Honduvilla Natalio TITLE=Unfolding the role of placental-derived Extracellular Vesicles in Pregnancy: From homeostasis to pathophysiology JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.1060850 DOI=10.3389/fcell.2022.1060850 ISSN=2296-634X ABSTRACT=

The human placenta is a critical structure with multiple roles in pregnancy, including fetal nutrition and support, immunological, mechanical and chemical barrier as well as an endocrine activity. Besides, a growing body of evidence highlight the relevance of this organ on the maternofetal wellbeing not only during gestation, but also from birth onwards. Extracellular vesicles (EVs) are complex macromolecular structures of different size and content, acting as carriers of a diverse set of molecules and information from donor to recipient cells. Since its early development, the production and function of placental-derived EVs are essential to ensure an adequate progress of pregnancy. In turn, the fetus receives and produce their own EVs, highlighting the importance of these components in the maternofetal communication. Moreover, several studies have shown the clinical relevance of EVs in different obstetric pathologies such as preeclampsia, infectious diseases or gestational diabetes, among others, suggesting that they could be used as pathophysiological biomarkers of these diseases. Overall, the aim of this article is to present an updated review of the published basic and translational knowledge focusing on the role of placental-derived EVs in normal and pathological pregnancies. We suggest as well future lines of research to take in this novel and promising field.