AUTHOR=Sun Cen-Cen , Li Li , Tao Hou-Quan , Jiang Zhi-Chen , Wang Liang , Wang Hui-Ju 

TITLE=The role of NLRP3 inflammasome in digestive system malignancy

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.1051612

DOI=10.3389/fcell.2022.1051612

ISSN=2296-634X

ABSTRACT=<p>Digestive system malignancies, the most common types of cancer and a major cause of death in the worldwide, are generally characterized by high morbidity, insidious symptoms and poor prognosis. NLRP3 inflammasome, the most studied inflammasome member, is considered to be crucial in tumorigenesis. In this paper, we reviewed its pro-tumorigenic and anti-tumorigenic properties in different types of digestive system malignancy depending on the types of cells, tissues and organs involved, which would provide promising avenue for exploring new anti-cancer therapies.</p>