AUTHOR=Rani Bhavna , Gupta Deepesh K. , Johansson Staffan , Kamranvar Siamak A. 

TITLE=Contribution of integrin adhesion to cytokinetic abscission and genomic integrity

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.1048717

DOI=10.3389/fcell.2022.1048717

ISSN=2296-634X

ABSTRACT=<p>Recent research shows that integrin-mediated adhesion contributes to the regulation of cell division at two key steps: the formation of the mitotic spindle at the mitotic entry and the final cytokinetic abscission at the mitotic exit. Failure in either of these processes will have a direct impact on the other in each round of the cell cycle and on the genomic integrity. This review aims to present how integrin signals are involved at these cell cycle stages under normal conditions and some safety mechanisms that may counteract the generation of aneuploid cells in cases of defective integrin signals.</p>