AUTHOR=Pirini Francesca , Cortesi Michela , Tumedei Maria Maddalena , Zanoni Michele , Ravaioli Sara , Bravaccini Sara 

TITLE=Tumor resident microbiota and response to therapies: An insight on tissue bacterial microbiota

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.1048360

DOI=10.3389/fcell.2022.1048360

ISSN=2296-634X

ABSTRACT=<p>The role of the intestinal microbiota in the promotion, progression, and response to therapies is gaining importance, but recent studies confirm the presence of microbiota also in the tumor, thus becoming a component of the tumor microenvironment. There is not much knowledge on the characteristics and mechanisms of action of the tumor resident microbiota, but there are already indications of its involvement in conditioning the response to therapies. In this review, we discuss recent publications on the interaction between microbiota and anticancer treatments, mechanisms of resistance and possible strategies for manipulating the microbiota that could improve treatments in a personalized medicine perspective.</p>