AUTHOR=Huang Shan , Shao Tinghui , Liu Hong , Li Tianfa , Gui Xianhua , Zhao Qianwen TITLE=Resident Fibroblast MKL1 Is Sufficient to Drive Pro-fibrogenic Response in Mice JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.812748 DOI=10.3389/fcell.2021.812748 ISSN=2296-634X ABSTRACT=
Fibrosis is an evolutionarily conserved pathophysiological process serving bifurcated purposes. On the one hand, fibrosis is essential for wound healing and contributes to the preservation of organ function. On the other hand, aberrant fibrogenic response may lead to tissue remodeling and precipitate organ failure. Recently lineage tracing studies have shown that resident fibroblasts are the primary mediator of fibrosis taking place in key organs such as the heart, the lungs, and the kidneys. Megakaryocytic leukemia 1 (MKL1) is transcriptional regulator involved in tissue fibrosis. Here we generated resident fibroblast conditional MKL1 knockout (CKO) mice by crossing the