AUTHOR=Chen Zheng , Guo Yingjie , Zhao Da , Zou Quan , Yu Fusheng , Zhang Lijun , Xu Lei 

TITLE=Comprehensive Analysis Revealed that CDKN2A is a Biomarker for Immune Infiltrates in Multiple Cancers

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.808208

DOI=10.3389/fcell.2021.808208

ISSN=2296-634X

ABSTRACT=<p>The <italic>CDKN2A</italic> (cyclin dependent kinase inhibitor 2A/multiple tumor suppressor 1) gene, also known as the <italic>P16</italic> gene, encodes multiple tumor suppressor 1 (<italic>MTS1</italic>), which belongs to the INK4 family. In tumor tissue, <italic>CDKN2A</italic> has a high expression level compared with normal tissue and reflects prognosis in tumor patients. Our research targeted the analysis of <italic>CDKN2A</italic> expression in 33 tumors and clinical parameters, patient prognosis and tumor immunity roles. The <italic>CDKN2A</italic> expression level was significantly correlated with the tumor mutation burden (TMB) in 10 tumors, and the expression of <italic>CDKN2A</italic> was also correlated with MSI (microsatellite instability) in 10 tumors. <italic>CDKN2A</italic> expression was associated with infiltrating lymphocyte (TIL) levels in 22 pancancers, thus suggesting that <italic>CDKN2A</italic> expression is associated with tumor immunity. Enrichment analysis indicated that <italic>CDKN2A</italic> expression was involved in natural killer cell-mediated cytotoxicity pathways, antigen processing and presentation, olfactory transduction pathways, and regulation of the autophagy pathway in multiple cancers. <italic>CDKN2A</italic> was significantly associated with several immune cell infiltrates in pantumors. <italic>CDKN2A</italic> may serve as a promising prognostic biomarker and is associated with immune infiltrates across cancers.</p>