AUTHOR=Lu Senxu , Ding Xiangyu , Wang Yuanhe , Hu Xiaoyun , Sun Tong , Wei Minjie , Wang Xiaobin , Wu Huizhe 

TITLE=The Relationship Between the Network of Non-coding RNAs-Molecular Targets and N6-Methyladenosine Modification in Colorectal Cancer

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.772542

DOI=10.3389/fcell.2021.772542

ISSN=2296-634X

ABSTRACT=<p>Recent accumulating researches implicate that non-coding RNAs (ncRNAs) including microRNA (miRNA), circular RNA (circRNA), and long non-coding RNA (lncRNAs) play crucial roles in colorectal cancer (CRC) initiation and development. Notably, N6-methyladenosine (m<sup>6</sup>A) methylation, the critical posttranscriptional modulators, exerts various functions in ncRNA metabolism such as stability and degradation. However, the interaction regulation network among ncRNAs and the interplay with m<sup>6</sup>A-related regulators has not been well documented, particularly in CRC. Here, we summarize the interaction networks and sub-networks of ncRNAs in CRC based on a data-driven approach from the publications (IF &gt; 6) in the last quinquennium (2016–2021). Further, we extend the regulatory pattern between the core m<sup>6</sup>A regulators and m<sup>6</sup>A-related ncRNAs in the context of CRC metastasis and progression. Thus, our review will highlight the clinical potential of ncRNAs and m<sup>6</sup>A modifiers as promising biomarkers and therapeutic targets for improving the diagnostic precision and treatment of CRC.</p>