AUTHOR=Wang Na , Li Ziyi , Li Shilun , Li Yukun , Gao Liu , Bao Xiaoxue , Wang Ke , Liu Chang , Xue Peng , Liu Sijing TITLE=Curculigoside Ameliorates Bone Loss by Influencing Mesenchymal Stem Cell Fate in Aging Mice JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.767006 DOI=10.3389/fcell.2021.767006 ISSN=2296-634X ABSTRACT=
Senile osteoporosis is characterized by increased bone loss and fat accumulation in marrow. Curculigoside (CCG) is the major bioactive component of Curculigo orchioides, which has been used as anti-osteoporosis therapy for elder patients since antiquity. We aimed to investigate the underlying mechanisms by which CCG regulated the bone-fat balance in marrow of aging mice. In our study, CCG treatment was identified to interfere with the stem cell lineage commitment both