AUTHOR=Chen Jiawen , Sun Tianyu , You Yan , Wu Buling , Wang Xiaofang , Wu Jingyi TITLE=Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.760532 DOI=10.3389/fcell.2021.760532 ISSN=2296-634X ABSTRACT=

Stem cells maintain a subtle balance between self-renewal and differentiation under the regulatory network supported by both intracellular and extracellular components. Proteoglycans are large glycoproteins present abundantly on the cell surface and in the extracellular matrix where they play pivotal roles in facilitating signaling transduction and maintaining stem cell homeostasis. In this review, we outline distinct proteoglycans profiles and their functions in the regulation of stem cell homeostasis, as well as recent progress and prospects of utilizing proteoglycans/glycosaminoglycans as a novel glycomics carrier or bio-active molecules in bone regeneration.