AUTHOR=Pan Jun , Ye Fang , Yu Chengxuan , Zhu Qinsheng , Li Jiaqi , Zhang Yaohui , Tian Hedi , Yao Yunjin , Zhu Minjie , Shen Yibin , Zhu Feng , Wang Yingying , Zhou Xinhui , Guo Guoji , Wu Yijun TITLE=Papillary Thyroid Carcinoma Landscape and Its Immunological Link With Hashimoto Thyroiditis at Single-Cell Resolution JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.758339 DOI=10.3389/fcell.2021.758339 ISSN=2296-634X ABSTRACT=
The tumor microenvironment heterogeneity of papillary thyroid cancer (PTC) is poorly characterized. The relationship between PTC and Hashimoto thyroiditis (HT) is also in doubt. Here, we used single-cell RNA sequencing to map the transcriptome landscape of PTC from eight PTC patients, of which three were concurrent with HT. Predicted copy number variation in epithelial cells and mesenchymal cells revealed the distinct molecular signatures of carcinoma cells. Carcinoma cells demonstrated intertumoral heterogeneity based on