AUTHOR=Luo Meng-Yi , Su Jian-Hui , Gong Shao-Xin , Liang Na , Huang Wen-Qian , Chen Wei , Wang Ai-Ping , Tian Ying TITLE=Ferroptosis: New Dawn for Overcoming the Cardio-Cerebrovascular Diseases JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.733908 DOI=10.3389/fcell.2021.733908 ISSN=2296-634X ABSTRACT=

The dynamic balance of cardiomyocytes and neurons is essential to maintain the normal physiological functions of heart and brain. If excessive cells die in tissues, serious Cardio-Cerebrovascular Diseases would occur, namely, hypertension, myocardial infarction, and ischemic stroke. The regulation of cell death plays a role in promoting or alleviating Cardio-Cerebrovascular Diseases. Ferroptosis is an iron-dependent new type of cell death that has been proved to occur in a variety of diseases. In our review, we focus on the critical role of ferroptosis and its regulatory mechanisms involved in Cardio-Cerebrovascular Diseases, and discuss the important function of ferroptosis-related inhibitors in order to propose potential implications for the prevention and treatment of Cardio-Cerebrovascular Diseases.