AUTHOR=Lewis David A. , Ly Tony 

TITLE=Cell Cycle Entry Control in Naïve and Memory CD8+ T Cells

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.727441

DOI=10.3389/fcell.2021.727441

ISSN=2296-634X

ABSTRACT=<p>CD8<sup>+</sup> T cells play important roles in immunity and immuno-oncology. Upon antigen recognition and co-stimulation, naïve CD8<sup>+</sup> T cells escape from dormancy to engage in a complex programme of cellular growth, cell cycle entry and differentiation, resulting in rapid proliferation cycles that has the net effect of producing clonally expanded, antigen-specific cytotoxic T lymphocytes (CTLs). A fraction of activated T cells will re-enter dormancy by differentiating into memory T cells, which have essential roles in adaptive immunity. In this review, we discuss the current understanding of cell cycle entry control in CD8<sup>+</sup> T cells and crosstalk between these mechanisms and pathways regulating immunological phenotypes.</p>