AUTHOR=Prodhomme Mélanie K. , Péricart Sarah , Pommier Roxane M. , Morel Anne-Pierre , Brunac Anne-Cécile , Franchet Camille , Moyret-Lalle Caroline , Brousset Pierre , Puisieux Alain , Hoffmann Jean-Sébastien , Tissier Agnès 

TITLE=Opposite Roles for ZEB1 and TMEJ in the Regulation of Breast Cancer Genome Stability

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.727429

DOI=10.3389/fcell.2021.727429

ISSN=2296-634X

ABSTRACT=<p>Breast cancer cells frequently acquire mutations in faithful DNA repair genes, as exemplified by BRCA-deficiency. Moreover, overexpression of an inaccurate DNA repair pathway may also be at the origin of the genetic instability arising during the course of cancer progression. The specific gain in expression of <italic>POLQ</italic>, encoding the error-prone DNA polymerase Theta (POLθ) involved in theta-mediated end joining (TMEJ), is associated with a characteristic mutational signature. To gain insight into the mechanistic regulation of <italic>POLQ</italic> expression, this review briefly presents recent findings on the regulation of <italic>POLQ</italic> in the claudin-low breast tumor subtype, specifically expressing transcription factors involved in epithelial-to-mesenchymal transition (EMT) such as ZEB1 and displaying a paucity in genomic abnormality.</p>