AUTHOR=Mehrmohamadi Mahya , Sepehri Mohammad Hossein , Nazer Naghme , Norouzi Mohammad Reza TITLE=A Comparative Overview of Epigenomic Profiling Methods JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.714687 DOI=10.3389/fcell.2021.714687 ISSN=2296-634X ABSTRACT=

In the past decade, assays that profile different aspects of the epigenome have grown exponentially in number and variation. However, standard guidelines for researchers to choose between available tools depending on their needs are lacking. Here, we introduce a comprehensive collection of the most commonly used bulk and single-cell epigenomic assays and compare and contrast their strengths and weaknesses. We summarize some of the most important technical and experimental parameters that should be considered for making an appropriate decision when designing epigenomic experiments.