AUTHOR=Zou Ming-Li , Teng Ying-Ying , Wu Jun-Jie , Liu Si-Yu , Tang Xiao-Yu , Jia Yuan , Chen Zhong-Hua , Zhang Kai-Wen , Sun Zi-Li , Li Xia , Ye Jun-Xing , Xu Rui-Sheng , Yuan Feng-Lai TITLE=Fibroblasts: Heterogeneous Cells With Potential in Regenerative Therapy for Scarless Wound Healing JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.713605 DOI=10.3389/fcell.2021.713605 ISSN=2296-634X ABSTRACT=

In recent years, research on wound healing has become increasingly in-depth, but therapeutic effects are still not satisfactory. Occasionally, pathological tissue repair occurs. Influencing factors have been proposed, but finding the turning point between normal and pathological tissue repair is difficult. Therefore, we focused our attention on the most basic level of tissue repair: fibroblasts. Fibroblasts were once considered terminally differentiated cells that represent a single cell type, and their heterogeneity was not studied until recently. We believe that subpopulations of fibroblasts play different roles in tissue repair, resulting in different repair results, such as the formation of normal scars in physiological tissue repair and fibrosis or ulcers in pathological tissue repair. It is also proposed that scarless healing can be achieved by regulating fibroblast subpopulations.