AUTHOR=Wang Peipei , Feng Mengdie , Han Guoqiang , Yin Rong , Li Yashu , Yao Shuxin , Lu Pengbo , Wang Yuhua , Zhang Haojian 

TITLE=RNA m6A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.710964

DOI=10.3389/fcell.2021.710964

ISSN=2296-634X

ABSTRACT=<p>N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is a commonly modification of mammalian mRNAs and plays key roles in various cellular processes. Emerging evidence reveals the importance of RNA m<sup>6</sup>A modification in maintaining stem cell function in normal hematopoiesis and leukemogenesis. In this review, we first briefly summarize the latest advances in RNA m<sup>6</sup>A biology, and further highlight the roles of m<sup>6</sup>A writers, readers and erasers in normal hematopoiesis and acute myeloid leukemia. Moreover, we also discuss the mechanisms of these m<sup>6</sup>A modifiers in preserving the function of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs), as well as potential strategies for targeting m<sup>6</sup>A modification related pathways. Overall, we provide a comprehensive summary and our insights into the field of RNA m<sup>6</sup>A in normal hematopoiesis and leukemia pathogenesis.</p>