AUTHOR=Liu Caojie , Kang Ning , Guo Yuchen , Gong Ping 

TITLE=Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.710203

DOI=10.3389/fcell.2021.710203

ISSN=2296-634X

ABSTRACT=<p><bold>Background:</bold> Regulation of gene expression is critical for stem cell differentiation, tissue development, and human health maintenance. Recently, epigenetic modifications of histone and chromatin remodeling have been verified as key controllers of gene expression and human diseases.</p><p><bold>Objective:</bold> In this study, we review the role of chromodomain helicase DNA-binding (CHD) proteins in stem cell differentiation, cell fate decision, and several known human developmental disorders and cancers.</p><p><bold>Conclusion:</bold> CHD proteins play a crucial role in stem cell differentiation and human diseases.</p>