AUTHOR=Chen Yunqing , Fan Hongyan , Wang Shijun , Tang Guanmin , Zhai Changlin , Shen Liang 

TITLE=Ferroptosis: A Novel Therapeutic Target for Ischemia-Reperfusion Injury

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.688605

DOI=10.3389/fcell.2021.688605

ISSN=2296-634X

ABSTRACT=<p>Ischemia-reperfusion (I/R) injury is a major cause of cell death and organ damage in numerous pathologies, including myocardial infarction, stroke, and acute kidney injury. Current treatment methods for I/R injury are limited. Ferroptosis, which is a newly uncovered type of regulated cell death characterized by iron overload and lipid peroxidation accumulation, has been investigated in various diseases. There is increasing evidence of a close association between ferroptosis and I/R injury, with ferroptosis frequently identified as a new therapeutic target for the management of I/R injury. This review summarizes the current status of ferroptosis and discusses its relationship with I/R injury, as well as potential treatment strategies targeting it.</p>