AUTHOR=Zhan Chuanchuan , Xu Chao , Chen Jiajun , Shen Chong , Li Jinkun , Wang Zichu , Ying Xiangrong , Luo Zhengang , Ren Yu , Wu Gangfeng , Zhang Haojie , Qian Manfei 

TITLE=Development and Validation of an IL6/JAK/STAT3-Related Gene Signature to Predict Overall Survival in Clear Cell Renal Cell Carcinoma

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.686907

DOI=10.3389/fcell.2021.686907

ISSN=2296-634X

ABSTRACT=<p><bold>Background:</bold> Traditional clinicopathological features (TNM, pathology grade) are often insufficient in predictive prognosis accuracy of clear cell renal cell carcinoma (ccRCC). The IL6-JAK-STAT3 pathway is aberrantly hyperactivated in many cancer types, and such hyperactivation is generally associated with a poor clinical prognosis implying that it can be used as a promising prognosis indicator. The relation between the IL6-JAK-STAT3 pathway and ccRCC remains unknown.</p><p><bold>Methods:</bold> We evaluated the levels of various cancer hallmarks and filtered out the promising risk hallmarks in ccRCC. Subsequently, a prognosis model based on these hallmark-related genes was established <italic>via</italic> weighted correlation network analysis and Cox regression analysis. Besides, we constructed a nomogram based on the previous model with traditional clinicopathological features to improve the predictive power and accuracy.</p><p><bold>Results:</bold> The IL6-JAK-STAT3 pathway was identified as the promising risk hallmarks in ccRCC, and the pathway-related prognosis model based on five genes was built. Also, the nomogram we developed demonstrated the strongest and most stable survival predictive ability.</p><p><bold>Conclusion:</bold> Our study would provide new insights for guiding individualized treatment of ccRCC patients.</p>