AUTHOR=Xie Xiaona , Cai Xueding , Tang Yemeng , Jiang Chunhui , Zhou Feng , Yang Lehe , Liu Zhiguo , Wang Liangxing , Zhao Haiyang , Zhao Chengguang , Huang Xiaoying TITLE=Flubendazole Elicits Antitumor Effects by Inhibiting STAT3 and Activating Autophagy in Non-small Cell Lung Cancer JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.680600 DOI=10.3389/fcell.2021.680600 ISSN=2296-634X ABSTRACT=
Non-small cell lung carcinoma (NSCLC) is a major neoplastic disease with a high mortality worldwide; however, effective treatment of this disease remains a challenge. Flubendazole, a traditional anthelmintic drug, possesses potent antitumor properties; however, the detailed molecular mechanism of flubendazole activity in NSCLC needs to be further explored. In the present study, flubendazole was found to exhibit valid antitumor activity