AUTHOR=Yu Jun , She Yuanchu , Ji Sheng-Jian 

TITLE=m6A Modification in Mammalian Nervous System Development, Functions, Disorders, and Injuries

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.679662

DOI=10.3389/fcell.2021.679662

ISSN=2296-634X

ABSTRACT=<p><italic>N</italic><sup>6</sup>-methyladenosine (m<sup>6</sup>A) modification, as the most prevalent internal modification on mRNA, has been implicated in many biological processes through regulating mRNA metabolism. Given that m<sup>6</sup>A modification is highly enriched in the mammalian brain, this dynamic modification provides a crucial new layer of epitranscriptomic regulation of the nervous system. Here, in this review, we summarize the recent progress on studies of m<sup>6</sup>A modification in the mammalian nervous system ranging from neuronal development to basic and advanced brain functions. We also highlight the detailed underlying mechanisms in each process mediated by m<sup>6</sup>A writers, erasers, and readers. Besides, the involvement of dysregulated m<sup>6</sup>A modification in neurological disorders and injuries is discussed as well.</p>