Jiong LinA Commentary on
Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction
by Giulitti, F., Petrungaro, S., Mandatori, S., Tomaipitinca, L., de Franchis, V., D'Amore, A., et al. (2021). Front. Cell Dev. Biol. 9:629182. doi: 10.3389/fcell.2021.629182
Recently, we read a paper in Frontiers in Cell and Developmental Biology “Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction.” Oleic Acid (OA) may be a promising drug candidate for the treatment of hepatocellular carcinoma (HCC). However, some problems existing in this paper need to be commented.
With great interest we read a paper “Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction” published in Frontiers in Cell and Developmental Biology (Giulitti et al., 2021). Blocking autophagy suppresses the growth of HCC cells (Zai et al., 2020). Authors indicated that OA induced cell death and reduced migration and invasion of the HCC cells, suggesting OA could be a promising drug candidate for the treatment of disease. However, some issues existing in this paper need to be commented.
In the paper, OA inhibited the invasion and migration of HCC cells after treatment with OA (300 μM) for 48 h (Figure 6). However, authors demonstrated that OA significantly suppressed cell proliferation and induced cell death of HCC cells after incubation with the same concentrations (300 μM) of OA for the same time (48 h) (Figures 3–5). These results strongly suggested that the cause responsible for inhibition of migration and invasion of cells could be due to apoptosis induction of OA. Authors could treat the cells with OA at a lower concentration or for a short time when studying the inherent effects of drugs on the migration and invasion ability of cells without apoptosis induction. This made the results more convincing.
Author Contributions
JL: study concept and design, data analysis, methodology, drafting manuscript, review and editing, and supervision.
Conflict of Interest
The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
Giulitti, F., Petrungaro, S., Mandatori, S., Tomaipitinca, L., de Franchis, V., D'Amore, A., et al. (2021). Anti-tumor effect of oleic acid in hepatocellular carcinoma cell lines via autophagy reduction. Front. Cell Dev. Biol. 9:629182. doi: 10.3389/fcell.2021.629182
Keywords: oleic acid, hepatocellular carcinoma, invasion, cell death, migration
Citation: Lin J (2021) Commentary: Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction. Front. Cell Dev. Biol. 9:677595. doi: 10.3389/fcell.2021.677595
Received: 08 March 2021; Accepted: 23 March 2021;
Published: 13 April 2021.
Edited by:
Claudia Tanja Mierke, Leipzig University, GermanyReviewed by:
Wei Chen, Stanford University, United StatesCopyright © 2021 Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jiong Lin, MTE1MDY5MjIxMCYjeDAwMDQwO3FxLmNvbQ==