AUTHOR=Chen Fengling , Chen Jiewen , Wang Hong , Tang Huayuan , Huang Lei , Wang Shijia , Wang Xinru , Fang Xi , Liu Jie , Li Li , Ouyang Kunfu , Han Zhen TITLE=Histone Lysine Methyltransferase SETD2 Regulates Coronary Vascular Development in Embryonic Mouse Hearts JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.651655 DOI=10.3389/fcell.2021.651655 ISSN=2296-634X ABSTRACT=
Congenital heart defects are the most common birth defect and have a clear genetic component, yet genomic structural variations or gene mutations account for only a third of the cases. Epigenomic dynamics during human heart organogenesis thus may play a critical role in regulating heart development. However, it is unclear how histone mark H3K36me3 acts on heart development. Here we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse heart epigenome.