AUTHOR=Weng Mingjiao , Feng Yukuan , He Yan , Yang Weiwei , Li Jing , Zhu Yuanyuan , Wang Tianzhen , Wang Chuhan , Zhang Xiao , Qiao Yu , Li Qi , Zhao Lingyu , Gao Shuangshu , Zhang Lei , Wu Yiqi , Zhao Ran , Wang Guangyu , Li Zhiwei , Jin Xiaoming , Zheng Tongsen , Li Xiaobo TITLE=Hypoxia-Induced LIN28A mRNA Promotes the Metastasis of Colon Cancer in a Protein-Coding-Independent Manner JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.642930 DOI=10.3389/fcell.2021.642930 ISSN=2296-634X ABSTRACT=
The hypoxic microenvironment is beneficial to the metastasis but not to the proliferation of cancer cells. However, the mechanisms regarding to hypoxia differentially regulating cancer metastasis and proliferation are largely unknown. In this study, we revealed that hypoxia induced the expression of LIN28A at mRNA level but segregated LIN28A mRNAs in the P-bodies and thus inhibits the production of LIN28A protein. This unexpected finding suggests that there may be non-coding role for LIN28A mRNA in the progression of colon cancer. We further showed that the non-coding LIN28A mRNA promotes the metastasis but not proliferation of colon cancer cells