AUTHOR=Sun Li , Fu Xiuling , Ma Gang , Hutchins Andrew P. TITLE=Chromatin and Epigenetic Rearrangements in Embryonic Stem Cell Fate Transitions JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.637309 DOI=10.3389/fcell.2021.637309 ISSN=2296-634X ABSTRACT=
A major event in embryonic development is the rearrangement of epigenetic information as the somatic genome is reprogrammed for a new round of organismal development. Epigenetic data are held in chemical modifications on DNA and histones, and there are dramatic and dynamic changes in these marks during embryogenesis. However, the mechanisms behind this intricate process and how it is regulating and responding to embryonic development remain unclear. As embryos develop from totipotency to pluripotency, they pass through several distinct stages that can be captured permanently or transiently