AUTHOR=Zhao Shizhen , Li Xiaotian , Li Xinping , Wei Xiaoyun , Wang Honggang 

TITLE=Hydrogen Sulfide Plays an Important Role in Diabetic Cardiomyopathy

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.627336

DOI=10.3389/fcell.2021.627336

ISSN=2296-634X

ABSTRACT=<p>Diabetic cardiomyopathy is an important complication of diabetes mellitus and the main cause of diabetes death. Diabetic cardiomyopathy is related with many factors, such as hyperglycemia, lipid accumulation, oxidative stress, myocarditis, and apoptosis. Hydrogen sulfide (H<sub>2</sub>S) is a newly discovered signal molecule, which plays an important role in many physiological and pathological processes. Recent studies have shown that H<sub>2</sub>S is involved in improving diabetic cardiomyopathy, but its mechanism has not been fully elucidated. This review summarizes the research on the roles and mechanisms of H<sub>2</sub>S in diabetic cardiomyopathy in recent years to provide the basis for in-depth research in the future.</p>