AUTHOR=Hua Yanan , Song Jinlian , Peng Cuixiu , Wang Runze , Ma Zhongliang , Zhang Jinyu , Zhang Zheng , Li Ning , Hou Lin 

TITLE=Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.620925

DOI=10.3389/fcell.2021.620925

ISSN=2296-634X

ABSTRACT=<p>A regulator of ribosome synthesis 1 (RRS1) was discovered in yeast and is mainly localized in the nucleolus and endoplasmic reticulum. It regulates ribosomal protein, RNA biosynthesis, and protein secretion and is closely involved in cellular senescence, cell cycle regulation, transcription, translation, oncogenic transformation etc., Mutations in the RRS1 gene are associated with the occurrence and development of Huntington’s disease and cancer, and overexpression of RRS1 promotes tumor growth and metastasis. In this review, the structure, function, and mechanisms of RRS1 in various diseases are discussed.</p>